Abstract Search

hrp0097fc3.2 | Fat, metabolism and obesity 1 | ESPE2023

Analysis of ligand- and mutation-dependent signaling of the melanocortin 4 receptor (MC4R): an example of the relevance of differential signaling (bias signaling)

Ruck Lisa , Paisdzior Sarah , Scheerer Patrick , Wiegand Susanna , Kleinau Gunnar , A. Heyder Nicolas , G. Beck-Sickinger Annette , C. Troll Manuel , Biebermann Heike , Kühnen Peter

Introduction: The melanocortin 4 receptor (MC4R) is a G protein coupled receptor (GPCR) and plays a pivotal role in the central regulation of body weight in the hypothalamus. In the context of the leptin-melanocortin signaling pathway, the MC4R is activated by the endogenous ligands a- and b-MSH (melanocyte-stimulating hormone). This leads to the feeling of satiety and to a reduction in food intake. Mutations within the genes leptin, leptin receptor (LEPR), pr...

1 shares

ESPE Abstracts

Analysis of ligand- and mutation-dependent signaling of the melanocortin 4 receptor (MC4R): an example of the relevance of differential signaling (bias signaling)

BiosciAbstracts